TERT promoter mutations are frequent in cutaneous basal cell carcinoma and squamous cell carcinoma.

Activating mutations in the TERT promoter were recently identified in up to 71% of cutaneous melanoma. Subsequent studies found TERT promoter mutations in a wide array of other major human cancers. TERT promoter mutations lead to increased expression of telomerase, which maintains telomere length an...

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Auteurs principaux: Klaus G Griewank, Rajmohan Murali, Bastian Schilling, Tobias Schimming, Inga Möller, Iris Moll, Marion Schwamborn, Antje Sucker, Lisa Zimmer, Dirk Schadendorf, Uwe Hillen
Format: Artigo
Langue:Inglês
Publié: Public Library of Science (PLoS) 2013-01-01
Collection:PLoS ONE
Accès en ligne:http://europepmc.org/articles/PMC3832433?pdf=render
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