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Structural and functional analyses of DNA-sensing and immune activation by human cGAS.

The detection of cytosolic DNA, derived from pathogens or host cells, by cytosolic receptors is essential for appropriate host immune responses. Cyclic GMP-AMP synthase (cGAS) is a newly identified cytosolic DNA receptor that produces cyclic GMP-AMP, which activates stimulator of interferon genes (S...

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Bibliografische gegevens
Hoofdauteurs: Kazuki Kato, Ryohei Ishii, Eiji Goto, Ryuichiro Ishitani, Fuminori Tokunaga, Osamu Nureki
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science (PLoS) 2013-01-01
Reeks:PLoS ONE
Online toegang:http://europepmc.org/articles/PMC3792152?pdf=render
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