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Structural and functional analyses of DNA-sensing and immune activation by human cGAS.
The detection of cytosolic DNA, derived from pathogens or host cells, by cytosolic receptors is essential for appropriate host immune responses. Cyclic GMP-AMP synthase (cGAS) is a newly identified cytosolic DNA receptor that produces cyclic GMP-AMP, which activates stimulator of interferon genes (S...
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Hoofdauteurs: | , , , , , |
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Formaat: | Artigo |
Taal: | Inglês |
Gepubliceerd in: |
Public Library of Science (PLoS)
2013-01-01
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Reeks: | PLoS ONE |
Online toegang: | http://europepmc.org/articles/PMC3792152?pdf=render |
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