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BRCA1 and homologous recombination: implications from mouse embryonic development
Abstract As an important player in DNA damage response, BRCA1 maintains genomic stability and suppresses tumorigenesis by promoting DNA double-strand break (DSB) repair through homologous recombination (HR). Since the cloning of BRCA1 gene, many Brca1 mutant alleles have been generated in mice. Mice...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BMC
2020-03-01
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| Colecção: | Cell & Bioscience |
| Acesso em linha: | http://link.springer.com/article/10.1186/s13578-020-00412-4 |
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