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SCN3A deficiency associated with increased seizure susceptibility

Mutations in voltage-gated sodium channels expressed highly in the brain (SCN1A, SCN2A, SCN3A, and SCN8A) are responsible for an increasing number of epilepsy syndromes. In particular, mutations in the SCN3A gene, encoding the pore-forming Nav1.3 α subunit, have been identified in patients with foca...

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Autori principali: Tyra Lamar, Carlos G. Vanoye, Jeffrey Calhoun, Jennifer C. Wong, Stacey B.B. Dutton, Benjamin S. Jorge, Milen Velinov, Andrew Escayg, Jennifer A. Kearney
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2017-06-01
Serie:Neurobiology of Disease
Soggetti:
SCN3A
Nav1.3
Focal epilepsy
Voltage-gated sodium channel
Seizure susceptibility
Accesso online:http://www.sciencedirect.com/science/article/pii/S0969996117300372
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