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Carvedilol increases seizure resistance in a mouse model of SCN8A-derived epilepsy

Patients with mutations that alter the function of the sodium channel SCN8A present with a range of clinical features, including mild to severe seizures, developmental delay, intellectual disability, autism, feeding dysfunction, motor impairment, and hypotonia. In an effort to identify compounds tha...

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Autors principals: Jennifer C. Wong, Andrew Escayg
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2024-06-01
Col·lecció:Frontiers in Pharmacology
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Accés en línia:https://www.frontiersin.org/articles/10.3389/fphar.2024.1397225/full
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