SCN3A deficiency associated with increased seizure susceptibility

Mutations in voltage-gated sodium channels expressed highly in the brain (SCN1A, SCN2A, SCN3A, and SCN8A) are responsible for an increasing number of epilepsy syndromes. In particular, mutations in the SCN3A gene, encoding the pore-forming Nav1.3 α subunit, have been identified in patients with foca...

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Autors principals:	Tyra Lamar, Carlos G. Vanoye, Jeffrey Calhoun, Jennifer C. Wong, Stacey B.B. Dutton, Benjamin S. Jorge, Milen Velinov, Andrew Escayg, Jennifer A. Kearney
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2017-06-01
Col·lecció:	Neurobiology of Disease
Matèries:	SCN3A Nav1.3 Focal epilepsy Voltage-gated sodium channel Seizure susceptibility
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S0969996117300372
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