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Analyses on clustering of the conserved residues at protein-RNA interfaces and its application in binding site identification

Abstract Background The maintenance of protein structural stability requires the cooperativity among spatially neighboring residues. Previous studies have shown that conserved residues tend to occur clustered together within enzyme active sites and protein-protein/DNA interfaces. It is possible that...

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Principais autores: Zhen Yang, Xueqing Deng, Yang Liu, Weikang Gong, Chunhua Li
פורמט: Artigo
שפה:Inglês
יצא לאור: BMC 2020-02-01
סדרה:BMC Bioinformatics
נושאים:
Protein-RNA interfaces
Conserved residues
Clustering characteristics
Hot spot residues
Binding site identification
גישה מקוונת:http://link.springer.com/article/10.1186/s12859-020-3398-9
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