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Analyses on clustering of the conserved residues at protein-RNA interfaces and its application in binding site identification

Abstract Background The maintenance of protein structural stability requires the cooperativity among spatially neighboring residues. Previous studies have shown that conserved residues tend to occur clustered together within enzyme active sites and protein-protein/DNA interfaces. It is possible that...

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Main Authors: Zhen Yang, Xueqing Deng, Yang Liu, Weikang Gong, Chunhua Li
Format: Artigo
Language:Inglês
Published: BMC 2020-02-01
Series:BMC Bioinformatics
Subjects:
Protein-RNA interfaces
Conserved residues
Clustering characteristics
Hot spot residues
Binding site identification
Online Access:http://link.springer.com/article/10.1186/s12859-020-3398-9
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