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Molecular determinants of allosteric modulation of protein disulfide isomerase by small-molecule b′-ligands

Allosteric modulation is central to enzyme function and an attractive strategy for drug development. Protein Disulfide Isomerase (PDI), the prototypical thiol-isomerase, exemplifies this potential through its structural flexibility and involvement in neurodegeneration, cancer, and thromboinflammator...

Whakaahuatanga katoa

I tiakina i:
Ngā kaituhi matua: Nathan Ponzar, Anna Pagotto, Srija Bandyopadhayay, Marvin J. Meyers, Vincenzo De Filippis, Robert Flaumenhaft, Nicola Pozzi
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Elsevier 2026-03-01
Rangatū:Redox Biology
Ngā marau:
Enzymology
Allostery
Thiol-isomerases
Drug discovery
Blood coagulation
Cancer
Urunga tuihono:http://www.sciencedirect.com/science/article/pii/S221323172600042X
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