QR Code

Molecular determinants of allosteric modulation of protein disulfide isomerase by small-molecule b′-ligands

Allosteric modulation is central to enzyme function and an attractive strategy for drug development. Protein Disulfide Isomerase (PDI), the prototypical thiol-isomerase, exemplifies this potential through its structural flexibility and involvement in neurodegeneration, cancer, and thromboinflammator...

Full description

Saved in:
Main Authors: Nathan Ponzar, Anna Pagotto, Srija Bandyopadhayay, Marvin J. Meyers, Vincenzo De Filippis, Robert Flaumenhaft, Nicola Pozzi
Format: Artigo
Language:Inglês
Published: Elsevier 2026-03-01
Series:Redox Biology
Subjects:
Enzymology
Allostery
Thiol-isomerases
Drug discovery
Blood coagulation
Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S221323172600042X
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items