Molecular determinants of allosteric modulation of protein disulfide isomerase by small-molecule b′-ligands

Allosteric modulation is central to enzyme function and an attractive strategy for drug development. Protein Disulfide Isomerase (PDI), the prototypical thiol-isomerase, exemplifies this potential through its structural flexibility and involvement in neurodegeneration, cancer, and thromboinflammator...

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Egile Nagusiak:	Nathan Ponzar, Anna Pagotto, Srija Bandyopadhayay, Marvin J. Meyers, Vincenzo De Filippis, Robert Flaumenhaft, Nicola Pozzi
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	Elsevier 2026-03-01
Saila:	Redox Biology
Gaiak:	Enzymology Allostery Thiol-isomerases Drug discovery Blood coagulation Cancer
Sarrera elektronikoa:	http://www.sciencedirect.com/science/article/pii/S221323172600042X
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