New Approach Methods for Hazard Identification: A Case Study with Azole Fungicides Affecting Molecular Targets Associated with the Adverse Outcome Pathway for Cholestasis

Triazole fungicides such as propiconazole (Pi) or tebuconazole (Te) show hepatotoxicity in vivo, e.g., hypertrophy and vacuolization of liver cells following interaction with nuclear receptors such as PXR (pregnane-X-receptor) and CAR (constitutive androstane receptor). Accordingly, azoles affect ge...

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Principais autores:	Constanze Knebel, Roderich D. Süssmuth, Helen S. Hammer, Albert Braeuning, Philip Marx-Stoelting
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2022-10-01
coleção:	Cells
Assuntos:	hepatotoxicity azole fungicides molecular targets adverse outcome pathway liver cholestasis
Acesso em linha:	https://www.mdpi.com/2073-4409/11/20/3293
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