New Approach Methods for Hazard Identification: A Case Study with Azole Fungicides Affecting Molecular Targets Associated with the Adverse Outcome Pathway for Cholestasis

Triazole fungicides such as propiconazole (Pi) or tebuconazole (Te) show hepatotoxicity in vivo, e.g., hypertrophy and vacuolization of liver cells following interaction with nuclear receptors such as PXR (pregnane-X-receptor) and CAR (constitutive androstane receptor). Accordingly, azoles affect ge...

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מידע ביבליוגרפי

Principais autores:	Constanze Knebel, Roderich D. Süssmuth, Helen S. Hammer, Albert Braeuning, Philip Marx-Stoelting
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	MDPI AG 2022-10-01
סדרה:	Cells
נושאים:	hepatotoxicity azole fungicides molecular targets adverse outcome pathway liver cholestasis
גישה מקוונת:	https://www.mdpi.com/2073-4409/11/20/3293
תגים:	הוספת תג אין תגיות, היה/י הראשונ/ה לתייג את הרשומה!