New Approach Methods for Hazard Identification: A Case Study with Azole Fungicides Affecting Molecular Targets Associated with the Adverse Outcome Pathway for Cholestasis

Triazole fungicides such as propiconazole (Pi) or tebuconazole (Te) show hepatotoxicity in vivo, e.g., hypertrophy and vacuolization of liver cells following interaction with nuclear receptors such as PXR (pregnane-X-receptor) and CAR (constitutive androstane receptor). Accordingly, azoles affect ge...

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Príomhchruthaitheoirí:	Constanze Knebel, Roderich D. Süssmuth, Helen S. Hammer, Albert Braeuning, Philip Marx-Stoelting
Formáid:	Artigo
Teanga:	Inglês
Foilsithe / Cruthaithe:	MDPI AG 2022-10-01
Sraith:	Cells
Ábhair:	hepatotoxicity azole fungicides molecular targets adverse outcome pathway liver cholestasis
Rochtain ar líne:	https://www.mdpi.com/2073-4409/11/20/3293
Clibeanna:	Cuir clib leis Níl clibeanna ann, Bí ar an gcéad duine le clib a chur leis an taifead seo!