New Approach Methods for Hazard Identification: A Case Study with Azole Fungicides Affecting Molecular Targets Associated with the Adverse Outcome Pathway for Cholestasis

Triazole fungicides such as propiconazole (Pi) or tebuconazole (Te) show hepatotoxicity in vivo, e.g., hypertrophy and vacuolization of liver cells following interaction with nuclear receptors such as PXR (pregnane-X-receptor) and CAR (constitutive androstane receptor). Accordingly, azoles affect ge...

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Manylion Llyfryddiaeth

Prif Awduron:	Constanze Knebel, Roderich D. Süssmuth, Helen S. Hammer, Albert Braeuning, Philip Marx-Stoelting
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	MDPI AG 2022-10-01
Cyfres:	Cells
Pynciau:	hepatotoxicity azole fungicides molecular targets adverse outcome pathway liver cholestasis
Mynediad Ar-lein:	https://www.mdpi.com/2073-4409/11/20/3293
Tagiau:	Ychwanegu Tag Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!