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Lorcaserin improves glycemic control via a melanocortin neurocircuit

Objective: The increasing prevalence of type 2 diabetes (T2D) and associated morbidity and mortality emphasizes the need for a more complete understanding of the mechanisms mediating glucose homeostasis to accelerate the identification of new medications. Recent reports indicate that the obesity med...

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Principais autores: Luke K. Burke, Emmanuel Ogunnowo-Bada, Teodora Georgescu, Claudia Cristiano, Pablo B. Martinez de Morentin, Lourdes Valencia Torres, Giuseppe D'Agostino, Christine Riches, Nicholas Heeley, Yue Ruan, Marcelo Rubinstein, Malcolm J. Low, Martin G. Myers, Justin J. Rochford, Mark L. Evans, Lora K. Heisler
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2017-10-01
Serier:Molecular Metabolism
Fag:
5-HT2c receptor
Type 2 diabetes
Hypothalamus
Lorcaserin
Pro-opiomelanocortin (POMC)
Melanocortin4 receptor (Mc4r)
Online adgang:http://www.sciencedirect.com/science/article/pii/S2212877817304258
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