The role of pro-opiomelanocortin in the ACTH–cortisol dissociation of sepsis

Abstract Background Sepsis is typically hallmarked by high plasma (free) cortisol and suppressed cortisol breakdown, while plasma adrenocorticotropic hormone (ACTH) is not increased, referred to as ‘ACTH–cortisol dissociation.’ We hypothesized that sepsis acutely activates the hypothalamus to genera...

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Autors principals:	Arno Téblick, Sarah Vander Perre, Lies Pauwels, Sarah Derde, Tim Van Oudenhove, Lies Langouche, Greet Van den Berghe
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2021-02-01
Col·lecció:	Critical Care
Matèries:	Sepsis Pituitary Adrenal Adrenocorticotropic hormone Pro-opiomelanocortin Glucocorticoid receptor
Accés en línia:	https://doi.org/10.1186/s13054-021-03475-y
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