Lorcaserin improves glycemic control via a melanocortin neurocircuit

Objective: The increasing prevalence of type 2 diabetes (T2D) and associated morbidity and mortality emphasizes the need for a more complete understanding of the mechanisms mediating glucose homeostasis to accelerate the identification of new medications. Recent reports indicate that the obesity med...

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Main Authors:	Luke K. Burke, Emmanuel Ogunnowo-Bada, Teodora Georgescu, Claudia Cristiano, Pablo B. Martinez de Morentin, Lourdes Valencia Torres, Giuseppe D'Agostino, Christine Riches, Nicholas Heeley, Yue Ruan, Marcelo Rubinstein, Malcolm J. Low, Martin G. Myers, Justin J. Rochford, Mark L. Evans, Lora K. Heisler
Format:	Artigo
Language:	Inglês
Published:	Elsevier 2017-10-01
Series:	Molecular Metabolism
Subjects:	5-HT2c receptor Type 2 diabetes Hypothalamus Lorcaserin Pro-opiomelanocortin (POMC) Melanocortin4 receptor (Mc4r)
Online Access:	http://www.sciencedirect.com/science/article/pii/S2212877817304258
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