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Variation in targetable genomic alterations in non-small cell lung cancer by genetic ancestry, sex, smoking history, and histology

Abstract Background Genomic alterations in 8 genes are now the targets of FDA-approved therapeutics in non-small cell lung cancer (NSCLC), but their distribution according to genetic ancestry, sex, histology, and smoking is not well established. Methods Using multi-institutional genetic testing data...

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Kaydedildi:
Asıl Yazarlar: Elio Adib, Amin H. Nassar, Sarah Abou Alaiwi, Stefan Groha, Elie W. Akl, Lynette M. Sholl, Kesi S. Michael, Mark M. Awad, Pasi A. Jӓnne, Alexander Gusev, David J. Kwiatkowski
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BMC 2022-04-01
Seri Bilgileri:Genome Medicine
Konular:
Non-small cell lung cancer
Targeted therapies
Targetable genomic alterations
Genetic ancestry
Smoking
Online Erişim:https://doi.org/10.1186/s13073-022-01041-x
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