Optimizing genetic ancestry adjustment in DNA methylation studies: a comparative analysis of approaches

Abstract Background Genetic ancestry is an important factor to account for in DNA methylation studies because genetic variation influences DNA methylation patterns. One approach uses principal components (PCs) calculated from CpG sites that overlap with common SNPs to adjust for ancestry when genoty...

Descrición completa

Detalles Bibliográficos

Principais autores:	Kira D. Höffler, Seyma Katrinli, Matthew W. Halvorsen, Anne-Kristin Stavrum, Kevin S. O’Connell, Alexey Shadrin, Srdjan Djurovic, Ole A. Andreassen, James J. Crowley, Jan Haavik, Kristen Hagen, Gerd Kvale, Kerry Ressler, Bjarne Hansen, Jair C. Soares, Gabriel R. Fries, Alicia K. Smith, Stéphanie Le Hellard
Formato:	Artigo
Idioma:	Inglês
Publicado:	BMC 2025-10-01
Series:	Epigenetics & Chromatin
Assuntos:	Epigenetics DNA methylation Ancestry EWAS MWAS
Acceso en liña:	https://doi.org/10.1186/s13072-025-00627-0
Tags:	Engadir etiqueta Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!