Optimizing genetic ancestry adjustment in DNA methylation studies: a comparative analysis of approaches

Abstract Background Genetic ancestry is an important factor to account for in DNA methylation studies because genetic variation influences DNA methylation patterns. One approach uses principal components (PCs) calculated from CpG sites that overlap with common SNPs to adjust for ancestry when genoty...

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Principais autores:	Kira D. Höffler, Seyma Katrinli, Matthew W. Halvorsen, Anne-Kristin Stavrum, Kevin S. O’Connell, Alexey Shadrin, Srdjan Djurovic, Ole A. Andreassen, James J. Crowley, Jan Haavik, Kristen Hagen, Gerd Kvale, Kerry Ressler, Bjarne Hansen, Jair C. Soares, Gabriel R. Fries, Alicia K. Smith, Stéphanie Le Hellard
Format:	Artigo
Jezik:	Inglês
Izdano:	BMC 2025-10-01
Serija:	Epigenetics & Chromatin
Teme:	Epigenetics DNA methylation Ancestry EWAS MWAS
Online dostop:	https://doi.org/10.1186/s13072-025-00627-0
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