Hyperactive KRAS/MAPK signaling disrupts normal lymphatic vessel architecture and function

Complex lymphatic anomalies (CLAs) are sporadically occurring diseases caused by the maldevelopment of lymphatic vessels. We and others recently reported that somatic activating mutations in KRAS can cause CLAs. However, the mechanisms by which activating KRAS mutations cause CLAs are poorly underst...

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書誌詳細

主要な著者:	Lorenzo M. Fernandes, Jeffrey Tresemer, Jing Zhang, Jonathan J. Rios, Joshua P. Scallan, Michael T. Dellinger
フォーマット:	Artigo
言語:	Inglês
出版事項:	Frontiers Media S.A. 2023-09-01
シリーズ:	Frontiers in Cell and Developmental Biology
主題:	complex lymphatic anomaly KRAS trametinib lymphangiogenesis lymphatic malformation Gorham-Stout disease
オンライン･アクセス:	https://www.frontiersin.org/articles/10.3389/fcell.2023.1276333/full
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