Hyperactive KRAS/MAPK signaling disrupts normal lymphatic vessel architecture and function

Complex lymphatic anomalies (CLAs) are sporadically occurring diseases caused by the maldevelopment of lymphatic vessels. We and others recently reported that somatic activating mutations in KRAS can cause CLAs. However, the mechanisms by which activating KRAS mutations cause CLAs are poorly underst...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής

Κύριοι συγγραφείς:	Lorenzo M. Fernandes, Jeffrey Tresemer, Jing Zhang, Jonathan J. Rios, Joshua P. Scallan, Michael T. Dellinger
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	Frontiers Media S.A. 2023-09-01
Σειρά:	Frontiers in Cell and Developmental Biology
Θέματα:	complex lymphatic anomaly KRAS trametinib lymphangiogenesis lymphatic malformation Gorham-Stout disease
Διαθέσιμο Online:	https://www.frontiersin.org/articles/10.3389/fcell.2023.1276333/full
Ετικέτες:	Προσθήκη ετικέτας Δεν υπάρχουν, Καταχωρήστε ετικέτα πρώτοι!