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Hyperactive KRAS/MAPK signaling disrupts normal lymphatic vessel architecture and function

Complex lymphatic anomalies (CLAs) are sporadically occurring diseases caused by the maldevelopment of lymphatic vessels. We and others recently reported that somatic activating mutations in KRAS can cause CLAs. However, the mechanisms by which activating KRAS mutations cause CLAs are poorly underst...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Lorenzo M. Fernandes, Jeffrey Tresemer, Jing Zhang, Jonathan J. Rios, Joshua P. Scallan, Michael T. Dellinger
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Frontiers Media S.A. 2023-09-01
Cyfres:Frontiers in Cell and Developmental Biology
Pynciau:
Mynediad Ar-lein:https://www.frontiersin.org/articles/10.3389/fcell.2023.1276333/full
Tagiau: Ychwanegu Tag
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