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Hyperactive KRAS/MAPK signaling disrupts normal lymphatic vessel architecture and function

Complex lymphatic anomalies (CLAs) are sporadically occurring diseases caused by the maldevelopment of lymphatic vessels. We and others recently reported that somatic activating mutations in KRAS can cause CLAs. However, the mechanisms by which activating KRAS mutations cause CLAs are poorly underst...

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Principais autores: Lorenzo M. Fernandes, Jeffrey Tresemer, Jing Zhang, Jonathan J. Rios, Joshua P. Scallan, Michael T. Dellinger
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2023-09-01
Serier:Frontiers in Cell and Developmental Biology
Fag:
complex lymphatic anomaly
KRAS
trametinib
lymphangiogenesis
lymphatic malformation
Gorham-Stout disease
Online adgang:https://www.frontiersin.org/articles/10.3389/fcell.2023.1276333/full
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