Predicting double-strand DNA breaks using epigenome marks or DNA at kilobase resolution

Abstract Double-strand breaks (DSBs) result from the attack of both DNA strands by multiple sources, including radiation and chemicals. DSBs can cause the abnormal chromosomal rearrangements associated with cancer. Recent techniques allow the genome-wide mapping of DSBs at high resolution, enabling...

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Главные авторы:	Raphaël Mourad, Krzysztof Ginalski, Gaëlle Legube, Olivier Cuvier
Формат:	Artigo
Язык:	Inglês
Опубликовано:	BMC 2018-03-01
Серии:	Genome Biology
Предметы:	Double-strand breaks Epigenetics Chromatin Machine learning
Online-ссылка:	http://link.springer.com/article/10.1186/s13059-018-1411-7
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