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Predicting double-strand DNA breaks using epigenome marks or DNA at kilobase resolution

Abstract Double-strand breaks (DSBs) result from the attack of both DNA strands by multiple sources, including radiation and chemicals. DSBs can cause the abnormal chromosomal rearrangements associated with cancer. Recent techniques allow the genome-wide mapping of DSBs at high resolution, enabling...

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Bibliografische gegevens
Hoofdauteurs: Raphaël Mourad, Krzysztof Ginalski, Gaëlle Legube, Olivier Cuvier
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BMC 2018-03-01
Reeks:Genome Biology
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Online toegang:http://link.springer.com/article/10.1186/s13059-018-1411-7
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