Impaired Autophagic Clearance with a Gain-of-Function Variant of the Lysosomal Cl<sup>−</sup>/H<sup>+</sup> Exchanger ClC-7
ClC-7 is a ubiquitously expressed voltage-gated Cl<sup>−</sup>/H<sup>+</sup> exchanger that critically contributes to lysosomal ion homeostasis. Together with its β-subunit Ostm1, ClC-7 localizes to lysosomes and to the ruffled border of osteoclasts, where it supports the acidification of the resorp...
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| Autores principales: | , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
MDPI AG
2023-12-01
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| Colección: | Biomolecules |
| Materias: | |
| Acceso en línea: | https://www.mdpi.com/2218-273X/13/12/1799 |
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