Impaired Autophagic Clearance with a Gain-of-Function Variant of the Lysosomal Cl⁻/H⁺ Exchanger ClC-7

ClC-7 is a ubiquitously expressed voltage-gated Cl⁻/H⁺ exchanger that critically contributes to lysosomal ion homeostasis. Together with its β-subunit Ostm1, ClC-7 localizes to lysosomes and to the ruffled border of osteoclasts, where it supports the acidification of the resorp...

Täydet tiedot

Bibliografiset tiedot

Päätekijät:	Shroddha Bose, Cecilia de Heus, Mary E. Kennedy, Fan Wang, Thomas J. Jentsch, Judith Klumperman, Tobias Stauber
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	MDPI AG 2023-12-01
Sarja:	Biomolecules
Aiheet:	autophagy chloride/proton exchange ClC-7 endo-lysosomes lysosomal storage disorder osmotic pressure
Linkit:	https://www.mdpi.com/2218-273X/13/12/1799
Tagit:	Lisää tagi Ei tageja, Lisää ensimmäinen tagi!