क्यूआर कोड

Impaired Autophagic Clearance with a Gain-of-Function Variant of the Lysosomal Cl<sup>−</sup>/H<sup>+</sup> Exchanger ClC-7

ClC-7 is a ubiquitously expressed voltage-gated Cl<sup>−</sup>/H<sup>+</sup> exchanger that critically contributes to lysosomal ion homeostasis. Together with its β-subunit Ostm1, ClC-7 localizes to lysosomes and to the ruffled border of osteoclasts, where it supports the acidification of the resorp...

पूर्ण विवरण

में बचाया:
मुख्य लेखकों: Shroddha Bose, Cecilia de Heus, Mary E. Kennedy, Fan Wang, Thomas J. Jentsch, Judith Klumperman, Tobias Stauber
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: MDPI AG 2023-12-01
श्रृंखला:Biomolecules
विषय:
autophagy
chloride/proton exchange
ClC-7
endo-lysosomes
lysosomal storage disorder
osmotic pressure
ऑनलाइन पहुंच:https://www.mdpi.com/2218-273X/13/12/1799
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