Simulation of pH-Dependent Conformational Transitions in Membrane Proteins: The CLC-ec1 Cl⁻/H⁺ Antiporter

Intracellular transport of chloride by members of the CLC transporter family involves a coupled exchange between a Cl⁻ anion and a proton (H⁺), which makes the transport function dependent on ambient pH. Transport activity peaks at pH 4.5 and stalls at neutral pH. However, a st...

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Bibliografiske detaljer

Principais autores:	Ekaterina Kots, Derek M. Shore, Harel Weinstein
Format:	Artigo
Sprog:	Inglês
Udgivet:	MDPI AG 2021-11-01
Serier:	Molecules
Fag:	CLC transporters pH-dependent activity molecular dynamics (MD) simulations high-resolution atomic force microscopy (HR-AFM) protonation state representations net charge conservation protocol
Online adgang:	https://www.mdpi.com/1420-3049/26/22/6956
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