Recognition motifs for importin 4 [(L)PPRS(G/P)P] and importin 5 [KP(K/Y)LV] binding, identified by bio-informatic simulation and experimental in vitro validation

Nuclear translocation of large proteins is mediated through karyopherins, carrier proteins recognizing specific motifs of cargo proteins, known as nuclear localization signals (NLS). However, only few NLS signals have been reported until now. In the present work, NLS signals for Importins 4 and 5 we...

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מידע ביבליוגרפי

Principais autores:	Athanasios A. Panagiotopoulos, Konstantina Kalyvianaki, Paraskevi K. Tsodoulou, Maria N. Darivianaki, Dimitris Dellis, George Notas, Vangelis Daskalakis, Panayiotis A. Theodoropoulos, Christos Α. Panagiotidis, Elias Castanas, Marilena Kampa
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	American Association for the Advancement of Science (AAAS) 2022-01-01
סדרה:	Computational and Structural Biotechnology Journal
נושאים:	Importin 4 Importin 5 Nuclear localization signal (NLS) Karyopherins
גישה מקוונת:	http://www.sciencedirect.com/science/article/pii/S2001037022004627
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