Recognition motifs for importin 4 [(L)PPRS(G/P)P] and importin 5 [KP(K/Y)LV] binding, identified by bio-informatic simulation and experimental in vitro validation

Nuclear translocation of large proteins is mediated through karyopherins, carrier proteins recognizing specific motifs of cargo proteins, known as nuclear localization signals (NLS). However, only few NLS signals have been reported until now. In the present work, NLS signals for Importins 4 and 5 we...

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Autors principals:	Athanasios A. Panagiotopoulos, Konstantina Kalyvianaki, Paraskevi K. Tsodoulou, Maria N. Darivianaki, Dimitris Dellis, George Notas, Vangelis Daskalakis, Panayiotis A. Theodoropoulos, Christos Α. Panagiotidis, Elias Castanas, Marilena Kampa
Format:	Artigo
Idioma:	Inglês
Publicat:	American Association for the Advancement of Science (AAAS) 2022-01-01
Col·lecció:	Computational and Structural Biotechnology Journal
Matèries:	Importin 4 Importin 5 Nuclear localization signal (NLS) Karyopherins
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2001037022004627
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