Recognition motifs for importin 4 [(L)PPRS(G/P)P] and importin 5 [KP(K/Y)LV] binding, identified by bio-informatic simulation and experimental in vitro validation

Nuclear translocation of large proteins is mediated through karyopherins, carrier proteins recognizing specific motifs of cargo proteins, known as nuclear localization signals (NLS). However, only few NLS signals have been reported until now. In the present work, NLS signals for Importins 4 and 5 we...

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Үндсэн зохиолчид:	Athanasios A. Panagiotopoulos, Konstantina Kalyvianaki, Paraskevi K. Tsodoulou, Maria N. Darivianaki, Dimitris Dellis, George Notas, Vangelis Daskalakis, Panayiotis A. Theodoropoulos, Christos Α. Panagiotidis, Elias Castanas, Marilena Kampa
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	American Association for the Advancement of Science (AAAS) 2022-01-01
Цуврал:	Computational and Structural Biotechnology Journal
Нөхцлүүд:	Importin 4 Importin 5 Nuclear localization signal (NLS) Karyopherins
Онлайн хандалт:	http://www.sciencedirect.com/science/article/pii/S2001037022004627
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!