Recognition motifs for importin 4 [(L)PPRS(G/P)P] and importin 5 [KP(K/Y)LV] binding, identified by bio-informatic simulation and experimental in vitro validation

Nuclear translocation of large proteins is mediated through karyopherins, carrier proteins recognizing specific motifs of cargo proteins, known as nuclear localization signals (NLS). However, only few NLS signals have been reported until now. In the present work, NLS signals for Importins 4 and 5 we...

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Detalles Bibliográficos

Principais autores:	Athanasios A. Panagiotopoulos, Konstantina Kalyvianaki, Paraskevi K. Tsodoulou, Maria N. Darivianaki, Dimitris Dellis, George Notas, Vangelis Daskalakis, Panayiotis A. Theodoropoulos, Christos Α. Panagiotidis, Elias Castanas, Marilena Kampa
Formato:	Artigo
Idioma:	Inglês
Publicado:	American Association for the Advancement of Science (AAAS) 2022-01-01
Series:	Computational and Structural Biotechnology Journal
Assuntos:	Importin 4 Importin 5 Nuclear localization signal (NLS) Karyopherins
Acceso en liña:	http://www.sciencedirect.com/science/article/pii/S2001037022004627
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