Dicloxacillin and Flucloxacillin Inhibit Hepatic Uptake Transporters—In Vitro Investigations and Physiologically Based Pharmacokinetic Modeling

ABSTRACT Dicloxacillin and flucloxacillin are β‐lactamase‐resistant penicillin antibiotics that have been in clinical use for over 50 years. While both antibiotics are known to induce cytochrome P450 enzymes, there is limited information available regarding their interactions with drug transporters....

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Detalhes bibliográficos

Principais autores:	Noora Sjöstedt, Ogochukwu U. Amaeze, Jeroen J. M. W. van denHeuvel, Tore B. Stage, Jan B. Koenderink, Nina Isoherranen, Heidi Kidron, Erkka Järvinen
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Wiley 2026-02-01
coleção:	Clinical and Translational Science
Assuntos:	antibiotics DDI drug–drug interaction in silico in vitro inhibition
Acesso em linha:	https://doi.org/10.1111/cts.70487
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