Dicloxacillin and Flucloxacillin Inhibit Hepatic Uptake Transporters—In Vitro Investigations and Physiologically Based Pharmacokinetic Modeling

ABSTRACT Dicloxacillin and flucloxacillin are β‐lactamase‐resistant penicillin antibiotics that have been in clinical use for over 50 years. While both antibiotics are known to induce cytochrome P450 enzymes, there is limited information available regarding their interactions with drug transporters....

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Bibliografische gegevens

Hoofdauteurs:	Noora Sjöstedt, Ogochukwu U. Amaeze, Jeroen J. M. W. van denHeuvel, Tore B. Stage, Jan B. Koenderink, Nina Isoherranen, Heidi Kidron, Erkka Järvinen
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	Wiley 2026-02-01
Reeks:	Clinical and Translational Science
Onderwerpen:	antibiotics DDI drug–drug interaction in silico in vitro inhibition
Online toegang:	https://doi.org/10.1111/cts.70487
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