Dicloxacillin and Flucloxacillin Inhibit Hepatic Uptake Transporters—In Vitro Investigations and Physiologically Based Pharmacokinetic Modeling

ABSTRACT Dicloxacillin and flucloxacillin are β‐lactamase‐resistant penicillin antibiotics that have been in clinical use for over 50 years. While both antibiotics are known to induce cytochrome P450 enzymes, there is limited information available regarding their interactions with drug transporters....

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής

Κύριοι συγγραφείς:	Noora Sjöstedt, Ogochukwu U. Amaeze, Jeroen J. M. W. van denHeuvel, Tore B. Stage, Jan B. Koenderink, Nina Isoherranen, Heidi Kidron, Erkka Järvinen
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	Wiley 2026-02-01
Σειρά:	Clinical and Translational Science
Θέματα:	antibiotics DDI drug–drug interaction in silico in vitro inhibition
Διαθέσιμο Online:	https://doi.org/10.1111/cts.70487
Ετικέτες:	Προσθήκη ετικέτας Δεν υπάρχουν, Καταχωρήστε ετικέτα πρώτοι!