HIV-1 gp120-induced lysosomal stress responses are controlled by TRPML1 redox sensors

Background Increased lysosomal stress responses (LSR) are commonly implicated in the pathogenesis of neurodegenerative disorders including HIV-1-associated neurocognitive disorders (HAND). The HIV-1 envelope glycoprotein gp120 causes LSR, increases levels of ferrous iron (Fe2+) in the cytosol and in...

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Autors principals:	Nirmal Kumar, Braelyn Liang, Jonathan D. Geiger
Format:	Artigo
Idioma:	Inglês
Publicat:	Taylor & Francis Group 2026-12-01
Col·lecció:	Redox Report
Matèries:	HIV-1 gp120 lysosomal stress responses reactive species interactome reactive sulfur species reactive nitrogen species reactive oxygen species
Accés en línia:	https://www.tandfonline.com/doi/10.1080/13510002.2026.2679333
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