Nicotinamide riboside modulates the reactive species interactome, bioenergetic status and proteomic landscape in a brain-region-specific manner

Summary: Nicotinamide riboside (NR), a precursor of nicotinamide adenine dinucleotide (NAD+), has robust cognitive benefits and alleviates neuroinflammation in Alzheimer's Disease (AD) mouse models without decreasing beta-amyloid plaque pathology. Such effects may be mediated by the reactive species...

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Hlavní autoři:	Alejandro Marmolejo-Garza, Laurent Chatre, Deborah L. Croteau, Alejandro Herron-Bedoya, Minh Danh Anh Luu, Benoit Bernay, Julien Pontin, Vilhelm A. Bohr, Erik Boddeke, Amalia M. Dolga
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2024-10-01
Edice:	Neurobiology of Disease
Témata:	Nicotinamide riboside Reactive species Interactome Alzheimer's disease Mitochondria Metabolism Neurodegeneration
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S0969996124002456
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