Vpu binds directly to tetherin and displaces it from nascent virions.
Tetherin (Bst2/CD317/HM1.24) is an interferon-induced antiviral host protein that inhibits the release of many enveloped viruses by tethering virions to the cell surface. The HIV-1 accessory protein, Vpu, antagonizes Tetherin through a variety of proposed mechanisms, including surface downregulation...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
Public Library of Science (PLoS)
2013-01-01
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| Σειρά: | PLoS Pathogens |
| Διαθέσιμο Online: | https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1003299&type=printable |
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