Polarity changes in the transmembrane domain core of HIV-1 Vpu inhibits its anti-tetherin activity.
Tetherin (BST-2/CD317) is an interferon-inducible antiviral protein that restricts the release of enveloped viruses from infected cells. The HIV-1 accessory protein Vpu can efficiently antagonize this restriction. In this study, we analyzed mutations of the transmembrane (TM) domain of Vpu, includin...
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| Hlavní autoři: | , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Public Library of Science (PLoS)
2011-01-01
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| Edice: | PLoS ONE |
| On-line přístup: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0020890&type=printable |
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