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The HIV-1 Vpu viroporin inhibitor BIT225 does not affect Vpu-mediated tetherin antagonism.

Among its many roles, the HIV-1 accessory protein Vpu performs a viroporin function and also antagonizes the host cell restriction factor tetherin through its transmembrane domain. BIT225 is a small molecule inhibitor that specifically targets the Vpu viroporin function, which, in macrophages, resul...

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מידע ביבליוגרפי
Principais autores: Björn D Kuhl, Vicky Cheng, Daniel A Donahue, Richard D Sloan, Chen Liang, John Wilkinson, Mark A Wainberg
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science (PLoS) 2011-01-01
סדרה:PLoS ONE
גישה מקוונת:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0027660&type=printable
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