Potential role of RhoA GTPase regulation in type interferon signaling in systemic lupus erythematosus

Abstract Objective Systemic lupus erythematosus (SLE) is an autoimmune disorder characterized by abnormal activation of the type I interferon (IFN) pathway, which results in tissue inflammation and organ damage. We explored the role of the RhoA GTPase in the type I IFN activation pathway to provide...

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Autori principali:	Wei Fan, Bo Wei, Xuyan Chen, Yi Zhang, Pingping Xiao, Kaiyan Li, Yi qin Zhang, Jinmei Huang, Lin Leng, Richard Bucala
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2024-01-01
Serie:	Arthritis Research & Therapy
Soggetti:	Autoimmunity Systemic lupus erythematosus RhoA Type I IFN RhoA/ROCK inhibitor
Accesso online:	https://doi.org/10.1186/s13075-024-03263-3
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