Potential role of RhoA GTPase regulation in type interferon signaling in systemic lupus erythematosus

Abstract Objective Systemic lupus erythematosus (SLE) is an autoimmune disorder characterized by abnormal activation of the type I interferon (IFN) pathway, which results in tissue inflammation and organ damage. We explored the role of the RhoA GTPase in the type I IFN activation pathway to provide...

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Detalles Bibliográficos

Principais autores:	Wei Fan, Bo Wei, Xuyan Chen, Yi Zhang, Pingping Xiao, Kaiyan Li, Yi qin Zhang, Jinmei Huang, Lin Leng, Richard Bucala
Formato:	Artigo
Idioma:	Inglês
Publicado:	BMC 2024-01-01
Series:	Arthritis Research & Therapy
Assuntos:	Autoimmunity Systemic lupus erythematosus RhoA Type I IFN RhoA/ROCK inhibitor
Acceso en liña:	https://doi.org/10.1186/s13075-024-03263-3
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