Nanopore sequencing of clonal IGH rearrangements in cell-free DNA as a biomarker for acute lymphoblastic leukemia

BackgroundAcute Lymphoblastic Leukemia (ALL) is the most common pediatric cancer, and patients with relapsed ALL have a poor prognosis. Detection of ALL blasts remaining at the end of treatment, or minimal residual disease (MRD), and spread of ALL into the central nervous system (CNS) have prognosti...

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Detalhes bibliográficos

Principais autores:	Shilpa Sampathi, Yelena Chernyavskaya, Meghan G. Haney, L. Henry Moore, Isabel A. Snyder, Anna H. Cox, Brittany L. Fuller, Tamara J. Taylor, Donglin Yan, Tom C. Badgett, Jessica S. Blackburn
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2022-12-01
coleção:	Frontiers in Oncology
Assuntos:	B-cell acute lymphoblastic leukemia (B-ALL) central nervous system (CNS) disease clonality minimal residual disease (MRD) relapse VDJ rearrangement
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fonc.2022.958673/full
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