Nanopore sequencing of clonal IGH rearrangements in cell-free DNA as a biomarker for acute lymphoblastic leukemia

BackgroundAcute Lymphoblastic Leukemia (ALL) is the most common pediatric cancer, and patients with relapsed ALL have a poor prognosis. Detection of ALL blasts remaining at the end of treatment, or minimal residual disease (MRD), and spread of ALL into the central nervous system (CNS) have prognosti...

Descrizione completa

Dettagli Bibliografici

Autori principali:	Shilpa Sampathi, Yelena Chernyavskaya, Meghan G. Haney, L. Henry Moore, Isabel A. Snyder, Anna H. Cox, Brittany L. Fuller, Tamara J. Taylor, Donglin Yan, Tom C. Badgett, Jessica S. Blackburn
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2022-12-01
Serie:	Frontiers in Oncology
Soggetti:	B-cell acute lymphoblastic leukemia (B-ALL) central nervous system (CNS) disease clonality minimal residual disease (MRD) relapse VDJ rearrangement
Accesso online:	https://www.frontiersin.org/articles/10.3389/fonc.2022.958673/full
Tags:	Aggiungi Tag Nessun Tag, puoi essere il primo ad aggiungerne!!