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Nanopore sequencing of clonal IGH rearrangements in cell-free DNA as a biomarker for acute lymphoblastic leukemia

BackgroundAcute Lymphoblastic Leukemia (ALL) is the most common pediatric cancer, and patients with relapsed ALL have a poor prognosis. Detection of ALL blasts remaining at the end of treatment, or minimal residual disease (MRD), and spread of ALL into the central nervous system (CNS) have prognosti...

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Príomhchruthaitheoirí: Shilpa Sampathi, Yelena Chernyavskaya, Meghan G. Haney, L. Henry Moore, Isabel A. Snyder, Anna H. Cox, Brittany L. Fuller, Tamara J. Taylor, Donglin Yan, Tom C. Badgett, Jessica S. Blackburn
Formáid: Artigo
Teanga:Inglês
Foilsithe / Cruthaithe: Frontiers Media S.A. 2022-12-01
Sraith:Frontiers in Oncology
Ábhair:
B-cell acute lymphoblastic leukemia (B-ALL)
central nervous system (CNS) disease
clonality
minimal residual disease (MRD)
relapse
VDJ rearrangement
Rochtain ar líne:https://www.frontiersin.org/articles/10.3389/fonc.2022.958673/full
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