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A N-terminal Truncated Intracellular Isoform of Matrix Metalloproteinase-2 Impairs Contractility of Mouse Myocardium

The full-length isoform of matrixmetalloproteinase-2 (FL-MMP-2) plays a role in turnover of the cardiac extracellular matrix. FL-MMP-2 is also present intracellularly in association with sarcomeres and, in the setting of oxidative stress, cleaves myofilament proteins with resultant impaired contract...

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Autori principali: David H Lovett, Charles eChu, Guanying eWang, Mark B Ratcliffe, Anthony J Baker
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2014-09-01
Serie:Frontiers in Physiology
Soggetti:
Heart Failure
Contraction
remodeling
MMP-2
Myofilament
Ca2+ transient
Accesso online:http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00363/full
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