A novel intracellular isoform of matrix metalloproteinase-2 induced by oxidative stress activates innate immunity.

Experimental and clinical evidence has pinpointed a critical role for matrix metalloproteinase-2 (MMP-2) in ischemic ventricular remodeling and systolic heart failure. Prior studies have demonstrated that transgenic expression of the full-length, 68 kDa, secreted form of MMP-2 induces severe systoli...

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Hlavní autoři:	David H Lovett, Rajeev Mahimkar, Robert L Raffai, Leslie Cape, Elena Maklashina, Gary Cecchini, Joel S Karliner
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Public Library of Science (PLoS) 2012-01-01
Edice:	PLoS ONE
On-line přístup:	http://europepmc.org/articles/PMC3317925?pdf=render
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